{"id":22,"date":"2024-01-16T09:34:05","date_gmt":"2024-01-16T08:34:05","guid":{"rendered":"https:\/\/contest-freezedrying.polito.it\/?page_id=22"},"modified":"2026-04-10T13:54:11","modified_gmt":"2026-04-10T11:54:11","slug":"info","status":"publish","type":"page","link":"https:\/\/contest-freezedrying.polito.it\/?page_id=22","title":{"rendered":"Student Contest Information"},"content":{"rendered":"\n<p>Students are asked to come up with an <strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-red-color\">innovative idea<\/mark><\/strong> regarding one of the challenges proposed by the Student Contest organizers. These challenges stem from actual problems and areas of improvement in the freeze-drying industry and R&amp;D; many of them concern pharmaceuticals and probiotics, but food sustainability, innovative energy production process and eco-sustainable processses are some of the other fields of growing interest:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2CB97A\" class=\"has-inline-color\"><strong>Energy Efficiency and Sustainable Refrigeration<\/strong><\/mark><\/strong>: Develop strategies to reduce the energy consumption of freeze-drying processes without compromising product quality. Proposals may include:\n<ul class=\"wp-block-list\">\n<li>Novel cycle optimization approaches<\/li>\n\n\n\n<li>Heat recovery strategies<\/li>\n\n\n\n<li>Life Cycle Assessment (LCA) analysis<\/li>\n\n\n\n<li>Replacement of CFCs, HCFCs, and high-GWP HFC refrigerants<\/li>\n\n\n\n<li>Adoption of natural or low-GWP refrigerants<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2CB97A\" class=\"has-inline-color\"><strong>Modeling, Simulation, and Digital Twins<\/strong><\/mark><\/strong>: Develop predictive models to optimize freeze-drying processes, including:\n<ul class=\"wp-block-list\">\n<li>Mechanistic modeling<\/li>\n\n\n\n<li>Machine learning\u2013based predictive tools<\/li>\n\n\n\n<li>Hybrid models (mechanistic + AI)<\/li>\n\n\n\n<li>Development of a digital twin of a freeze-dryer<\/li>\n\n\n\n<li>Robustness and scalability analysis<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2cb97a\" class=\"has-inline-color\"><strong>Smart and Automated Freeze-Drying<\/strong><\/mark><\/strong>: Design intelligent control systems capable of real-time process adaptation:\n<ul class=\"wp-block-list\">\n<li>Closed-loop control strategies<\/li>\n\n\n\n<li>Real-time primary drying endpoint detection<\/li>\n\n\n\n<li>Adaptive collapse temperature control<\/li>\n\n\n\n<li>Integration with PAT tools<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2CB97A\" class=\"has-inline-color\"><strong>Advanced Process Sensing (PAT)<\/strong><\/mark><\/strong>:Propose innovative monitoring solutions for real-time assessment of product state and critical quality attributes:\n<ul class=\"wp-block-list\">\n<li>Spectroscopic tools (NIR, Raman)<\/li>\n\n\n\n<li>TDLAS-based moisture detection<\/li>\n\n\n\n<li>Wireless in-vial sensors<\/li>\n\n\n\n<li>Thermal imaging<\/li>\n\n\n\n<li>Non-invasive moisture measurement<\/li>\n\n\n\n<li>Other proposed techniques\u2026<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2CB97A\" class=\"has-inline-color\"><strong>Continuous vs. Batch Freeze-Drying<\/strong><\/mark><\/strong>: Design of innovative concept for continuous lyo technologies and\/or perform a comparative technical and economic analysis of continuous and batch processes, including:\n<ul class=\"wp-block-list\">\n<li>Energy consumption<\/li>\n\n\n\n<li>CAPEX and OPEX considerations<\/li>\n\n\n\n<li>Scalability<\/li>\n\n\n\n<li>GMP implications<\/li>\n\n\n\n<li>Industrial feasibility<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2CB97A\" class=\"has-inline-color\"><strong>AI-Based Product Quality Assessment<\/strong><\/mark><\/strong>: Develop artificial intelligence systems for automated evaluation of:\n<ul class=\"wp-block-list\">\n<li>Cake morphology<\/li>\n\n\n\n<li>Structural defects<\/li>\n\n\n\n<li>Product integrity<\/li>\n\n\n\n<li>Batch-to-batch variability<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2CB97A\" class=\"has-inline-color\"><strong>Organic Solvent-Based Freeze-Drying<\/strong><\/mark><\/strong>: Address challenges in freeze-drying pharmaceutical formulations containing organic solvents:\n<ul class=\"wp-block-list\">\n<li>Safe industrial solvent management<\/li>\n\n\n\n<li>Compliance with ICH Q8 and residual solvent guidelines<\/li>\n\n\n\n<li>Morphology modification through solvent engineering<\/li>\n\n\n\n<li>Accelerated drying strategies<\/li>\n\n\n\n<li>Novel solvent\u2013excipient combinations<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2CB97A\" class=\"has-inline-color\"><strong>Innovative Containers and Packaging<\/strong><\/mark><\/strong>: Design non-conventional containers or closure systems for freeze-drying:\n<ul class=\"wp-block-list\">\n<li>Engineered primary packaging materials<\/li>\n\n\n\n<li>Improved heat transfer performance<\/li>\n\n\n\n<li>Integrated process monitoring containers<\/li>\n\n\n\n<li>Novel stopper or closure systems addressing specific industrial needs<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2cb97a\" class=\"has-inline-color\">3D Printing and Structured Porous Systems<\/mark><\/strong><\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2cb97a\" class=\"has-inline-color\">Explore the integration of additive manufacturing technologies to create optimized porous structures for freeze-drying applications.<\/mark><\/strong><\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2cb97a\" class=\"has-inline-color\">Freeze-Dried Drug Delivery Systems<\/mark><\/strong><\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2cb97a\" class=\"has-inline-color\">Develop innovative freeze-dried platforms to deliver drugs (e.g. small molecules, biologics, biotechnologics and nanovectors) via parenteral, transdermal, mucosal, oral, ocular and pulmonary routes.<\/mark><\/strong><\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2cb97a\" class=\"has-inline-color\">Freeze-Dried Diagnostic Kits<\/mark><\/strong><\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2cb97a\" class=\"has-inline-color\">Design and develop diagnostic kits leveraging freeze-drying to improve stability, transportability, and field usability.<\/mark><\/strong><\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2cb97a\" class=\"has-inline-color\">Freeze-dried scaffold to tissue engineering<\/mark><\/strong><\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2cb97a\" class=\"has-inline-color\">Propose strategies to tailor the physical and biological properties of freeze-dried scaffolds for tissue engineering.<\/mark><\/strong><\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2cb97a\" class=\"has-inline-color\">Valorization of biomass<\/mark><\/strong><\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2cb97a\" class=\"has-inline-color\">Define advanced freeze-drying\u2013based methodologies for the conversion of biomass into high-performance functional materials intended for food, cosmetic, and pharmaceutical applications<\/mark><\/strong><\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2cb97a\" class=\"has-inline-color\">Sustainability and Green Lyophilization<\/mark><\/strong><\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2cb97a\" class=\"has-inline-color\">Propose solutions aimed at reducing the environmental footprint of freeze-drying, including:<\/mark><\/strong>\n<ul class=\"wp-block-list\">\n<li>Carbon footprint reduction<\/li>\n\n\n\n<li>Water usage optimization<\/li>\n\n\n\n<li>Energy-efficient chamber design<\/li>\n\n\n\n<li>Rapid cycle freeze-drying strategies<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Students are asked to come up with an innovative idea regarding one of the challenges proposed by the Student Contest organizers. These challenges stem from actual problems and areas of improvement in the freeze-drying industry and R&amp;D; many of them &hellip; <a href=\"https:\/\/contest-freezedrying.polito.it\/?page_id=22\">Continua a leggere<span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-22","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/contest-freezedrying.polito.it\/index.php?rest_route=\/wp\/v2\/pages\/22","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/contest-freezedrying.polito.it\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/contest-freezedrying.polito.it\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/contest-freezedrying.polito.it\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/contest-freezedrying.polito.it\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22"}],"version-history":[{"count":4,"href":"https:\/\/contest-freezedrying.polito.it\/index.php?rest_route=\/wp\/v2\/pages\/22\/revisions"}],"predecessor-version":[{"id":196,"href":"https:\/\/contest-freezedrying.polito.it\/index.php?rest_route=\/wp\/v2\/pages\/22\/revisions\/196"}],"wp:attachment":[{"href":"https:\/\/contest-freezedrying.polito.it\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}